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Manfred Jung
Manfred Jung
Institute of Pharmaceutical Sciences, University of Freiburg; former University of Münster, Ottawa
Bestätigte E-Mail-Adresse bei pharmazie.uni-freiburg.de - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
K Keller, M Jung
Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches …, 2013
4722013
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
L Morera, M Lübbert, M Jung
Clinical epigenetics 8, 1-16, 2016
4422016
SIRT1 regulates HIV transcription via Tat deacetylation
S Pagans, A Pedal, BJ North, K Kaehlcke, BL Marshall, A Dorr, ...
PLoS biology 3 (2), e41, 2005
4362005
Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ...
Journal of medicinal chemistry 61 (2), 482-491, 2018
3162018
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ...
Nature communications 6 (1), 6263, 2015
2992015
HDAC8: a multifaceted target for therapeutic interventions
A Chakrabarti, I Oehme, O Witt, G Oliveira, W Sippl, C Romier, RJ Pierce, ...
Trends in pharmacological sciences 36 (7), 481-492, 2015
2982015
Inhibitors of histone deacetylase as new anticancer agents
M Jung
Current Medicinal Chemistry 8 (12), 1505-1511, 2001
2862001
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation
M Jung, G Brosch, D Kölle, H Scherf, C Gerhäuser, P Loidl
Journal of Medicinal Chemistry 42 (22), 4669-4679, 1999
2651999
Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins)
J Trapp, R Meier, D Hongwiset, MU Kassack, W Sippl, M Jung
ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1419-1431, 2007
2442007
Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni
M Marek, S Kannan, AT Hauser, M Moraes Mourão, S Caby, V Cura, ...
PLoS pathogens 9 (9), e1003645, 2013
2082013
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
A Spannhoff, AT Hauser, R Heinke, W Sippl, M Jung
ChemMedChem: Chemistry Enabling Drug Discovery 4 (10), 1568-1582, 2009
2072009
Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
RC Neugebauer, U Uchiechowska, R Meier, H Hruby, V Valkov, E Verdin, ...
Journal of medicinal chemistry 51 (5), 1203-1213, 2008
2062008
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition
J Trapp, A Jochum, R Meier, L Saunders, B Marshall, C Kunick, E Verdin, ...
Journal of medicinal chemistry 49 (25), 7307-7316, 2006
2062006
Target-based approach to inhibitors of histone arginine methyltransferases
A Spannhoff, R Heinke, I Bauer, P Trojer, E Metzger, R Gust, R Schüle, ...
Journal of medicinal chemistry 50 (10), 2319-2325, 2007
1742007
Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors
Y Zhang, M Jung, A Dritschilo, M Jung
Radiation research 161 (6), 667-674, 2004
1742004
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates
SW Remiszewski, LC Sambucetti, P Atadja, KW Bair, WD Cornell, ...
Journal of medicinal chemistry 45 (4), 753-757, 2002
1722002
Subtype selective substrates for histone deacetylases
B Heltweg, F Dequiedt, BL Marshall, C Brauch, M Yoshida, N Nishino, ...
Journal of medicinal chemistry 47 (21), 5235-5243, 2004
1642004
Impairment of prostate cancer cell growth by a selective and reversible LSD1 inhibitor
D Willmann, S Lim, S Wetzel, E Metzger, A Jandausch, W Wilk, M Jung, ...
International Journal of Cancer 128, 574-586, 2012
157*2012
In vitro assays for the determination of histone deacetylase activity
B Heltweg, J Trapp, M Jung
Methods 36 (4), 332-337, 2005
1562005
Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo
JM Gajer, SD Furdas, A Gründer, M Gothwal, U Heinicke, K Keller, ...
Oncogenesis 4 (2), e137-e137, 2015
1532015
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