| Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine T Krojer, M Garrido-Franco, R Huber, M Ehrmann, T Clausen Nature 416 (6879), 455-459, 2002 | 499 | 2002 |
| Structural basis for the regulated protease and chaperone function of DegP T Krojer, J Sawa, E Schäfer, HR Saibil, M Ehrmann, T Clausen Nature 453 (7197), 885-890, 2008 | 440 | 2008 |
| Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ... Journal of Biological Chemistry 288 (11), 7803-7814, 2013 | 309 | 2013 |
| Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ... Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011 | 284 | 2011 |
| Rapid covalent-probe discovery by electrophile-fragment screening E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ... Journal of the American Chemical Society 141 (22), 8951-8968, 2019 | 276 | 2019 |
| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8, 15123, 2017 | 260 | 2017 |
| SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 199 | 2022 |
| A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ... Chemical science 7 (3), 2322-2330, 2016 | 179 | 2016 |
| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013 | 179 | 2013 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012 | 166 | 2012 |
| Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins T Krojer, K Pangerl, J Kurt, J Sawa, C Stingl, K Mechtler, R Huber, ... Proceedings of the National Academy of Sciences 105 (22), 7702-7707, 2008 | 161 | 2008 |
| Substrate-induced remodeling of the active site regulates human HTRA1 activity L Truebestein, A Tennstaedt, T Mönig, T Krojer, F Canellas, M Kaiser, ... Nature Structural and Molecular Biology 18 (3), 386, 2011 | 159 | 2011 |
| Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 148 | 2021 |
| HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues T Krojer, J Sawa, R Huber, T Clausen Nature Structural and Molecular Biology 17 (7), 844, 2010 | 142 | 2010 |
| Ribosomal oxygenases are structurally conserved from prokaryotes to humans R Chowdhury, R Sekirnik, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, ... Nature 510 (7505), 422-426, 2014 | 127 | 2014 |
| Gentle, fast and effective crystal soaking by acoustic dispensing PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ... Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017 | 109 | 2017 |
| Crystal structure of the 2-oxoglutarate-and Fe (II)-dependent lysyl hydroxylase JMJD6 M Mantri, T Krojer, EA Bagg, CJ Webby, DS Butler, G Kochan, ... Journal of molecular biology 401 (2), 211-222, 2010 | 109 | 2010 |
| The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ... Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017 | 107 | 2017 |
| Structural and mechanistic studies on γ-butyrobetaine hydroxylase IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ... Chemistry & biology 17 (12), 1316-1324, 2010 | 106 | 2010 |
| 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ... Journal of medicinal chemistry 59 (4), 1388-1409, 2016 | 104 | 2016 |
