| The Mitsunobu reaction in the 21 st century S Fletcher Organic Chemistry Frontiers 2 (6), 739-752, 2015 | 321 | 2015 |
| A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson Biochemical pharmacology 79 (10), 1398-1409, 2010 | 228 | 2010 |
| Targeting protein–protein interactions by rational design: mimicry of protein surfaces S Fletcher, AD Hamilton Journal of the Royal Society Interface 3 (7), 215-233, 2006 | 202 | 2006 |
| Small-molecule inhibitors of the Myc oncoprotein S Fletcher, EV Prochownik Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (5), 525-543, 2015 | 183 | 2015 |
| Protein surface recognition and proteomimetics: mimics of protein surface structure and function S Fletcher, AD Hamilton Current opinion in chemical biology 9 (6), 632-638, 2005 | 174 | 2005 |
| Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain P Mistry, MHW Laird, RS Schwarz, S Greene, T Dyson, GA Snyder, ... Proceedings of the National Academy of Sciences 112 (17), 5455-5460, 2015 | 172 | 2015 |
| Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein S Fletcher, J Turkson, PT Gunning ChemMedChem 3 (8), 1159, 2008 | 143 | 2008 |
| The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition C Peddaboina, D Jupiter, S Fletcher, JL Yap, A Rai, RP Tobin, W Jiang, ... BMC cancer 12, 1-12, 2012 | 142 | 2012 |
| Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning Biochemistry and Cell Biology 87 (6), 825-833, 2009 | 134 | 2009 |
| Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ... Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009 | 122 | 2009 |
| Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ... Journal of medicinal chemistry 55 (3), 1047-1055, 2012 | 121 | 2012 |
| Perturbation of the c-Myc–Max protein–protein interaction via synthetic α-helix mimetics KY Jung, H Wang, P Teriete, JL Yap, L Chen, ME Lanning, A Hu, ... Journal of medicinal chemistry 58 (7), 3002-3024, 2015 | 112 | 2015 |
| The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein … X Cao, JL Yap, MK Newell-Rogers, C Peddaboina, W Jiang, ... Molecular cancer 12, 1-16, 2013 | 104 | 2013 |
| Small molecule inhibitors of the ERK signalling pathway: towards novel anti-cancer therapeutics JL Yap, S Worlikar, AD MacKerell Jr, P Shapiro, S Fletcher ChemMedChem 6 (1), 38, 2011 | 101 | 2011 |
| BRD4 structure–activity relationships of dual PLK1 kinase/BRD4 bromodomain inhibitor BI-2536 L Chen, JL Yap, M Yoshioka, ME Lanning, RN Fountain, M Raje, ... ACS medicinal chemistry letters 6 (7), 764-769, 2015 | 98 | 2015 |
| Protein-protein interaction inhibitors: small molecules from screening techniques S Fletcher, AD Hamilton Current topics in medicinal chemistry 7 (10), 922-927, 2007 | 98 | 2007 |
| Expanding the cancer arsenal with targeted therapies: Disarmament of the antiapoptotic Bcl-2 proteins by small molecules: Miniperspective JL Yap, L Chen, ME Lanning, S Fletcher Journal of medicinal chemistry 60 (3), 821-838, 2017 | 97 | 2017 |
| Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-x L inhibitors JL Yap, X Cao, K Vanommeslaeghe, KY Jung, C Peddaboina, PT Wilder, ... Organic & Biomolecular Chemistry 10 (15), 2928-2933, 2012 | 90 | 2012 |
| Pharmacophore identification of c-Myc inhibitor 10074-G5 JL Yap, H Wang, A Hu, J Chauhan, KY Jung, RB Gharavi, EV Prochownik, ... Bioorganic & medicinal chemistry letters 23 (1), 370-374, 2013 | 87 | 2013 |
| Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ... Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011 | 75 | 2011 |
Patrick T. GunningCanada Research Chair and Associate Professor of ChemistryBestätigte E-Mail-Adresse bei utoronto.ca