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David Fidock
David Fidock
Professor of Microbiology & Immunology and of Medical Sciences (in Medicine), Columbia University
Verificeret mail på columbia.edu - Startside
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Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock, T Nomura, AK Talley, RA Cooper, SM Dzekunov, MT Ferdig, ...
Molecular cell 6 (4), 861-871, 2000
19062000
A molecular marker for chloroquine-resistant falciparum malaria
A Djimdé, OK Doumbo, JF Cortese, K Kayentao, S Doumbo, Y Diourté, ...
New England journal of medicine 344 (4), 257-263, 2001
13052001
Antimalarial drug discovery: efficacy models for compound screening
DA Fidock, PJ Rosenthal, SL Croft, R Brun, S Nwaka
Nature reviews Drug discovery 3 (6), 509-520, 2004
12512004
Spiroindolones, a potent compound class for the treatment of malaria
M Rottmann, C McNamara, BKS Yeung, MCS Lee, B Zou, B Russell, ...
science 329 (5996), 1175-1180, 2010
12462010
Malaria: progress, perils, and prospects for eradication
BM Greenwood, DA Fidock, DE Kyle, SHI Kappe, PL Alonso, FH Collins, ...
The Journal of clinical investigation 118 (4), 1266-1276, 2008
10882008
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
ABS Sidhu, D Verdier-Pinard, DA Fidock
Science 298 (5591), 210-213, 2002
9962002
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
J Straimer, NF Gnädig, B Witkowski, C Amaratunga, V Duru, ...
Science 347 (6220), 428-431, 2015
8102015
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
RT Eastman, DA Fidock
Nature Reviews Microbiology 7 (12), 864-874, 2009
7012009
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
A Uwimana, E Legrand, BH Stokes, JLM Ndikumana, M Warsame, ...
Nature medicine 26 (10), 1602-1608, 2020
6832020
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil
DA Fidock, TE Wellems
Proceedings of the National Academy of Sciences 94 (20), 10931-10936, 1997
6071997
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock
Nature medicine 23 (8), 917-928, 2017
5952017
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
D Ménard, N Khim, J Beghain, AA Adegnika, M Shafiul-Alam, O Amodu, ...
New England Journal of Medicine 374 (25), 2453-2464, 2016
5822016
Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin
ABS Sidhu, AC Uhlemann, SG Valderramos, JC Valderramos, S Krishna, ...
The Journal of infectious diseases 194 (4), 528-535, 2006
5172006
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
ABS Sidhu, SG Valderramos, DA Fidock
Molecular microbiology 57 (4), 913-926, 2005
4772005
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
4682015
Targeting Plasmodium PI(4)K to eliminate malaria
CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland, A Nagle, O Simon, ...
Nature 504 (7479), 248-253, 2013
4582013
Artemisinin action and resistance in Plasmodium falciparum
L Tilley, J Straimer, NF Gnädig, SA Ralph, DA Fidock
Trends in parasitology 32 (9), 682-696, 2016
4142016
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study
B Witkowski, V Duru, N Khim, LS Ross, B Saintpierre, J Beghain, S Chy, ...
The Lancet Infectious Diseases 17 (2), 174-183, 2017
3922017
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
S Meister, DM Plouffe, KL Kuhen, GMC Bonamy, T Wu, SW Barnes, ...
Science 334 (6061), 1372-1377, 2011
3822011
PfCRT and its role in antimalarial drug resistance
A Ecker, AM Lehane, J Clain, DA Fidock
Trends in parasitology 28 (11), 504-514, 2012
3672012
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Artikler 1–20