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Yuting Guan
Yuting Guan
Verificeret mail på bio.ecnu.edu.cn
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Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
D Li, Z Qiu, Y Shao, Y Chen, Y Guan, M Liu, Y Li, N Gao, L Wang, X Lu, ...
Nature biotechnology 31 (8), 681-683, 2013
8722013
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos
Y Shao, Y Guan, L Wang, Z Qiu, M Liu, Y Chen, L Wu, Y Li, X Ma, M Liu, ...
Nature protocols 9 (10), 2493-2512, 2014
2192014
CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse
Y Guan, Y Ma, Q Li, Z Sun, L Ma, L Wu, L Wang, L Zeng, Y Shao, Y Chen, ...
EMBO molecular medicine 8 (5), 477-488, 2016
2092016
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
X Sheng, Y Guan, Z Ma, J Wu, H Liu, C Qiu, S Vitale, Z Miao, MJ Seasock, ...
Nature genetics 53 (9), 1322-1333, 2021
1192021
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos
L Wang, Y Shao, Y Guan, L Li, L Wu, F Chen, M Liu, H Chen, Y Ma, X Ma, ...
Scientific reports 5 (1), 17517, 2015
1072015
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
L Chen, B Zhu, G Ru, H Meng, Y Yan, M Hong, D Zhang, C Luan, S Zhang, ...
Nature Biotechnology 41 (5), 663-672, 2023
932023
Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease
C Gluck, C Qiu, SY Han, M Palmer, J Park, YA Ko, Y Guan, X Sheng, ...
Nature communications 10 (1), 2461, 2019
762019
Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis
T Doke, S Huang, C Qiu, H Liu, Y Guan, H Hu, Z Ma, J Wu, Z Miao, ...
The Journal of clinical investigation 131 (10), 2021
622021
Functional methylome analysis of human diabetic kidney disease
J Park, Y Guan, X Sheng, C Gluck, MJ Seasock, AA Hakimi, C Qiu, ...
JCI insight 4 (11), 2019
622019
Adenine transversion editors enable precise, efficient A• T-to-C• G base editing in mammalian cells and embryos
L Chen, M Hong, C Luan, H Gao, G Ru, X Guo, D Zhang, S Zhang, C Li, ...
Nature biotechnology 42 (4), 638-650, 2024
612024
Lgr4-mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis
Y Qian, S Liu, Y Guan, H Pan, X Guan, Z Qiu, L Li, N Gao, Y Zhao, X Li, ...
Development 140 (8), 1751-1761, 2013
572013
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Y Guan, X Liang, Z Ma, H Hu, H Liu, Z Miao, A Linkermann, JN Hellwege, ...
Nature communications 12 (1), 5078, 2021
542021
Lgr4 Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice*♦
S Liu, Y Qian, L Li, G Wei, Y Guan, H Pan, X Guan, L Zhang, X Lu, Y Zhao, ...
Journal of Biological Chemistry 288 (13), 8794-8803, 2013
522013
Repression of mammalian target of rapamycin complex 1 inhibits intestinal regeneration in acute inflammatory bowel disease models
Y Guan, L Zhang, X Li, X Zhang, S Liu, N Gao, L Li, G Gao, G Wei, Z Chen, ...
The Journal of immunology 195 (1), 339-346, 2015
462015
DNMT1 in Six2 progenitor cells is essential for transposable element silencing and kidney development
SY Li, J Park, Y Guan, K Chung, R Shrestha, MB Palmer, K Susztak
Journal of the American Society of Nephrology 30 (4), 594-609, 2019
412019
Lgr4 Gene Regulates Corpus Luteum Maturation Through Modulation of the WNT-Mediated EGFR-ERK Signaling Pathway
H Pan, H Cui, S Liu, Y Qian, H Wu, L Li, Y Guan, X Guan, L Zhang, ...
Endocrinology 155 (9), 3624-3637, 2014
382014
Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor
S Yin, L Ma, T Shao, M Zhang, Y Guan, L Wang, Y Hu, X Chen, H Han, ...
Science China Life Sciences, 1-13, 2020
202020
Dnmt3a and Dnmt3b-decommissioned fetal enhancers are linked to kidney disease
Y Guan, H Liu, Z Ma, SY Li, J Park, X Sheng, K Susztak
Journal of the American Society of Nephrology 31 (4), 765-782, 2020
182020
Generation of site-specific mutations in the rat genome via CRISPR/Cas9
Y Guan, Y Shao, D Li, M Liu
Methods in Enzymology 546, 297-317, 2014
172014
Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies
S Yin, M Zhang, Y Liu, X Sun, Y Guan, X Chen, L Yang, Y Huo, J Yang, ...
Molecular Therapy 31 (3), 744-759, 2023
162023
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