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David J. Polhemus MD, PhD
David J. Polhemus MD, PhD
The Johns Hopkins Hospital
Verificeret mail på jh.edu
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Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease
DJ Polhemus, DJ Lefer
Circulation research 114 (4), 730-737, 2014
5192014
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent
AL King, DJ Polhemus, S Bhushan, H Otsuka, K Kondo, CK Nicholson, ...
Proceedings of the National Academy of Sciences 111 (8), 3182-3187, 2014
4052014
Choline diet and its gut microbe–derived metabolite, trimethylamine N-oxide, exacerbate pressure overload–induced heart failure
CL Organ, H Otsuka, S Bhushan, Z Wang, J Bradley, R Trivedi, ...
Circulation: Heart Failure 9 (1), e002314, 2016
3692016
Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis
DJ Polhemus, K Kondo, S Bhushan, SC Bir, CG Kevil, T Murohara, ...
Circulation: Heart Failure 6 (5), 1077-1086, 2013
1932013
A novel hydrogen sulfide prodrug, SG 1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients
DJ Polhemus, Z Li, CB Pattillo, G Gojon Sr, G Gojon Jr, T Giordano, ...
Cardiovascular therapeutics 33 (4), 216-226, 2015
1702015
Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease
Z Li, DJ Polhemus, DJ Lefer
Circulation Research 123 (5), 590-600, 2018
1262018
The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure
DJ Polhemus, JW Calvert, J Butler, DJ Lefer
Scientifica 2014 (1), 768607, 2014
1202014
Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system
TE Sharp III, DJ Polhemus, Z Li, P Spaletra, JS Jenkins, JP Reilly, ...
Journal of the American College of Cardiology 72 (21), 2609-2621, 2018
972018
Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney
DJ Polhemus, RK Trivedi, J Gao, Z Li, AL Scarborough, TT Goodchild, ...
Journal of the American College of Cardiology 70 (17), 2139-2153, 2017
902017
Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
CL Organ, Z Li, TE Sharp III, DJ Polhemus, N Gupta, TT Goodchild, ...
Journal of the American Heart Association 9 (10), e016223, 2020
822020
Zofenopril protects against myocardial ischemia–reperfusion injury by increasing nitric oxide and hydrogen sulfide bioavailability
E Donnarumma, MJ Ali, AM Rushing, AL Scarborough, JM Bradley, ...
Journal of the American Heart Association 5 (7), e003531, 2016
762016
Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide–mediated cytoprotective signaling
S Bhushan, K Kondo, DJ Polhemus, H Otsuka, CK Nicholson, YX Tao, ...
Circulation research 114 (8), 1281-1291, 2014
752014
Combined angiotensin receptor–neprilysin inhibitors improve cardiac and vascular function via increased no bioavailability in heart failure
RK Trivedi, DJ Polhemus, Z Li, D Yoo, H Koiwaya, A Scarborough, ...
Journal of the American Heart Association 7 (5), e008268, 2018
612018
Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF 2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)
KN Islam, DJ Polhemus, E Donnarumma, LP Brewster, DJ Lefer
Journal of the American Heart Association 4 (5), e001986, 2015
612015
Radiofrequency renal denervation protects the ischemic heart via inhibition of GRK2 and increased nitric oxide signaling
DJ Polhemus, J Gao, AL Scarborough, R Trivedi, KH McDonough, ...
Circulation research 119 (3), 470-480, 2016
542016
Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells
Z Cheng, VNS Garikipati, E Nickoloff, C Wang, DJ Polhemus, J Zhou, ...
Circulation 134 (19), 1467-1483, 2016
532016
Effects of storage‐aged red blood cell transfusions on endothelial function in hospitalized patients
R Neuman, S Hayek, A Rahman, JC Poole, V Menon, S Sher, JL Newman, ...
Transfusion 55 (4), 782-790, 2015
482015
Hydrogen sulfide attenuates renin angiotensin and aldosterone pathological signaling to preserve kidney function and improve exercise tolerance in heart failure
Z Li, CL Organ, J Kang, DJ Polhemus, RK Trivedi, TE Sharp, JS Jenkins, ...
JACC: Basic to Translational Science 3 (6), 796-809, 2018
412018
Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia
AM Rushing, E Donnarumma, DJ Polhemus, KR Au, SE Victoria, ...
Journal of vascular surgery 69 (6), 1924-1935, 2019
382019
Novel göttingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities
TE Sharp III, AL Scarborough, Z Li, DJ Polhemus, HA Hidalgo, ...
Basic to Translational Science 6 (2), 154-170, 2021
362021
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