| Accurate prediction of protein structures and interactions using a three-track neural network M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ... Science 373 (6557), 871-876, 2021 | 4163 | 2021 |
| An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex KC Garcia, M Degano, RL Stanfield, A Brunmark, MR Jackson, ... Science 274 (5285), 209-219, 1996 | 1567 | 1996 |
| STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1 CY Park, PJ Hoover, FM Mullins, P Bachhawat, ED Covington, S Raunser, ... Cell 136 (5), 876-890, 2009 | 1147 | 2009 |
| Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis C Eroglu, NJ Allen, MW Susman, NA O'Rourke, CY Park, E Özkan, ... Cell 139 (2), 380-392, 2009 | 997 | 2009 |
| Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 989 | 2013 |
| Structural basis of Wnt recognition by Frizzled CY Janda, D Waghray, AM Levin, C Thomas, KC Garcia Science 337 (6090), 59-64, 2012 | 982 | 2012 |
| Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen KC Garcia, M Degano, LR Pease, M Huang, PA Peterson, L Teyton, ... Science 279 (5354), 1166-1172, 1998 | 871 | 1998 |
| Mutational signature in colorectal cancer caused by genotoxic pks+E. coli C Pleguezuelos-Manzano, J Puschhof, A Rosendahl Huber, A van Hoeck, ... Nature 580 (7802), 269-273, 2020 | 832 | 2020 |
| Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex MJ Boulanger, D Chow, EE Brevnova, KC Garcia Science 300 (5628), 2101-2104, 2003 | 809 | 2003 |
| Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells JA Fraietta, CL Nobles, MA Sammons, S Lundh, SA Carty, TJ Reich, ... Nature 558 (7709), 307-312, 2018 | 775 | 2018 |
| Structural basis of T cell recognition KC Garcia, L Teyton, IA Wilson Annual review of immunology 17 (1), 369-397, 1999 | 692 | 1999 |
| Deconstructing the peptide-MHC specificity of T cell recognition ME Birnbaum, JL Mendoza, DK Sethi, S Dong, J Glanville, J Dobbins, ... Cell 157 (5), 1073-1087, 2014 | 618 | 2014 |
| Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude, D Fernandez, ... Nature 603 (7900), 321-327, 2022 | 617 | 2022 |
| Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system SL LaPorte, ZS Juo, J Vaclavikova, LA Colf, X Qi, NM Heller, AD Keegan, ... Cell 132 (2), 259-272, 2008 | 598 | 2008 |
| Screening and large-scale expression of membrane proteins in mammalian cells for structural studies A Goehring, CH Lee, KH Wang, JC Michel, DP Claxton, I Baconguis, ... Nature protocols 9 (11), 2574-2585, 2014 | 587 | 2014 |
| Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ AM Levin, DL Bates, AM Ring, C Krieg, JT Lin, L Su, I Moraga, ME Raeber, ... Nature 484 (7395), 529-533, 2012 | 576 | 2012 |
| Structure of the Quaternary Complex of Interleukin-2 with Its α, β, and γc Receptors X Wang, M Rickert, KC Garcia Science 310 (5751), 1159-1163, 2005 | 574 | 2005 |
| Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies K Weiskopf, AM Ring, CCM Ho, JP Volkmer, AM Levin, AK Volkmer, ... Science 341 (6141), 88-91, 2013 | 559 | 2013 |
| Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody AM Ring, A Manglik, AC Kruse, MD Enos, WI Weis, KC Garcia, BK Kobilka Nature 502 (7472), 575-579, 2013 | 553 | 2013 |
| The composition and signaling of the IL-35 receptor are unconventional LW Collison, GM Delgoffe, CS Guy, KM Vignali, V Chaturvedi, ... Nature immunology 13 (3), 290-299, 2012 | 539 | 2012 |