| Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3‐only Bcl‐2 family member Bim T Akiyama, P Bouillet, T Miyazaki, Y Kadono, H Chikuda, U Chung, ... The EMBO journal, 2003 | 322 | 2003 |
| Akt1 in osteoblasts and osteoclasts controls bone remodeling N Kawamura, F Kugimiya, Y Oshima, S Ohba, T Ikeda, T Saito, Y Shinoda, ... PloS one 2 (10), e1058, 2007 | 304 | 2007 |
| RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis J Gohda, T Akiyama, T Koga, H Takayanagi, S Tanaka, J Inoue The EMBO journal 24 (4), 790-799, 2005 | 257 | 2005 |
| Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database T Akiyama, H Chikuda, H Yasunaga, H Horiguchi, K Fushimi, K Saita BMJ open 3 (3), e002412, 2013 | 228 | 2013 |
| Bim-targeted cancer therapy: a link between drug action and underlying molecular changes T Akiyama, CR Dass, PFM Choong Molecular cancer therapeutics 8 (12), 3173-3180, 2009 | 200 | 2009 |
| Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway T Akiyama, CR Dass, PFM Choong Molecular cancer therapeutics 7 (11), 3461-3469, 2008 | 170 | 2008 |
| Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1 A Fukuda, A Hikita, H Wakeyama, T Akiyama, H Oda, K Nakamura, ... Journal of bone and mineral research 20 (12), 2245-2253, 2005 | 104 | 2005 |
| Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy M Tomek, T Akiyama, CR Dass Journal of Pharmacy and Pharmacology 64 (12), 1695-1702, 2012 | 101 | 2012 |
| PEDF regulates osteoclasts via osteoprotegerin and RANKL T Akiyama, CR Dass, Y Shinoda, H Kawano, S Tanaka, PFM Choong Biochemical and Biophysical Research Communications 391 (1), 789-794, 2010 | 98 | 2010 |
| Suppression of arthritic bone destruction by adenovirus‐mediated dominant‐negative Ras gene transfer to synoviocytes and osteoclasts A Yamamoto, A Fukuda, H Seto, T Miyazaki, Y Kadono, Y Sawada, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2003 | 80 | 2003 |
| Molecular mechanism of the life and death of the osteoclast S Tanaka, T Miyazaki, A Fukuda, T Akiyama, Y Kadono, H Wakeyama, ... Annals of the New York Academy of Sciences 1068 (1), 180-186, 2006 | 78 | 2006 |
| Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts Y Nagase, M Iwasawa, T Akiyama, Y Kadono, M Nakamura, Y Oshima, ... Journal of Biological Chemistry 284 (52), 36659-36669, 2009 | 63 | 2009 |
| The significance of size change of soft tissue sarcoma during preoperative radiotherapy Y Miki, S Ngan, JCM Clark, T Akiyama, PFM Choong European Journal of Surgical Oncology (EJSO) 36 (7), 678-683, 2010 | 60 | 2010 |
| Negative Feedback Loop in the Bim–Caspase‐3 Axis Regulating Apoptosis and Activity of Osteoclasts H Wakeyama, T Akiyama, K Takahashi, H Amano, Y Kadono, ... Journal of Bone and Mineral Research 22 (10), 1631-1639, 2007 | 59 | 2007 |
| Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis Y Oshima, T Akiyama, A Hikita, M Iwasawa, Y Nagase, M Nakamura, ... Journal of biological chemistry 283 (39), 26499-26508, 2008 | 58 | 2008 |
| The non-vascularised fibular graft: a simple and successful method of reconstruction of the pelvic ring after internal hemipelvectomy T Akiyama, JCM Clark, Y Miki, PFM Choong The Journal of Bone & Joint Surgery British Volume 92 (7), 999-1005, 2010 | 57 | 2010 |
| The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice M Iwasawa, T Miyazaki, Y Nagase, T Akiyama, Y Kadono, M Nakamura, ... The Journal of clinical investigation 119 (10), 3149-3159, 2009 | 55 | 2009 |
| The pathophysiological role of PEDF in bone diseases ML Broadhead, T Akiyama, PFM Choong, CR Dass Current Molecular Medicine 10 (3), 296-301, 2010 | 46 | 2010 |
| Reliability and validity of a Japanese-language and culturally adapted version of the musculoskeletal tumor society scoring system for the lower extremity S Iwata, K Uehara, K Ogura, T Akiyama, Y Shinoda, T Yonemoto, A Kawai Clinical Orthopaedics and Related Research® 474, 2044-2052, 2016 | 37 | 2016 |
| Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts T Akiyama, CR Dass, Y Shinoda, H Kawano, S Tanaka, PFM Choong Journal of Pharmacy and Pharmacology 62 (4), 470-476, 2010 | 37 | 2010 |
