| Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor RJ Andersen, NR Mawji, J Wang, G Wang, S Haile, JK Myung, K Watt, ... Cancer cell 17 (6), 535-546, 2010 | 620 | 2010 |
| An androgen receptor N-terminal domain antagonist for treating prostate cancer JK Myung, CA Banuelos, JG Fernandez, NR Mawji, J Wang, AH Tien, ... The Journal of clinical investigation 123 (7), 2948-2960, 2013 | 358 | 2013 |
| Role of molecular chaperones in steroid receptor action WB Pratt, MD Galigniana, Y Morishima, PJM Murphy Essays in biochemistry 40, 41-58, 2004 | 342 | 2004 |
| Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100 J Richards, AC Lim, CW Hay, AE Taylor, A Wingate, K Nowakowska, ... Cancer research 72 (9), 2176-2182, 2012 | 305 | 2012 |
| Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations DN Lavery, IJ McEwan Biochemical Journal 391 (3), 449-464, 2005 | 292 | 2005 |
| The evolution of the nuclear receptor superfamily H Escriva, S Bertrand, V Laudet Essays in biochemistry 40, 11-26, 2004 | 251 | 2004 |
| Mechanism of gene expression by the glucocorticoid receptor: role of protein‐protein interactions IJ McEwan, APH Wright, JÅ Gustafsson Bioessays 19 (2), 153-160, 1997 | 245 | 1997 |
| Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF IJ McEwan, JÅ Gustafsson Proceedings of the National Academy of Sciences 94 (16), 8485-8490, 1997 | 242 | 1997 |
| Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain. IJ McEwan Endocrine-related cancer 11 (2), 281-293, 2004 | 225 | 2004 |
| Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor. K Dahlman-Wright, H Baumann, IJ McEwan, T Almlöf, AP Wright, ... Proceedings of the National Academy of Sciences 92 (5), 1699-1703, 1995 | 218 | 1995 |
| Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation: influence of structure-stabilizing solutes and protein-protein interactions J Reid, SM Kelly, K Watt, NC Price, IJ McEwan Journal of Biological Chemistry 277 (22), 20079-20086, 2002 | 204 | 2002 |
| Nuclear receptors: one big family IJ McEwan The Nuclear Receptor Superfamily: Methods and Protocols, 3-18, 2009 | 188 | 2009 |
| DNA recognition by nuclear receptors F Claessens, DT Gewirth Essays in biochemistry 40, 59-72, 2004 | 166 | 2004 |
| Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors. JC Rowlands, IJ Mcewan, JA Gustafsson Molecular pharmacology 50 (3), 538-548, 1996 | 157 | 1996 |
| Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding IJ McEwan, K Dahlman-Wright, J Ford, APH Wright Biochemistry 35 (29), 9584-9593, 1996 | 153 | 1996 |
| EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor E De Mol, RB Fenwick, CTW Phang, V Buzon, E Szulc, A De La Fuente, ... ACS chemical biology 11 (9), 2499-2505, 2016 | 148 | 2016 |
| Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation R Kumar, IJ McEwan Endocrine reviews 33 (2), 271-299, 2012 | 148 | 2012 |
| Regulation of the androgen receptor by SET9-mediated methylation L Gaughan, J Stockley, N Wang, SRC McCracken, A Treumann, ... Nucleic acids research 39 (4), 1266-1279, 2011 | 147 | 2011 |
| Induced α-helix structure in AF1 of the androgen receptor upon binding transcription factor TFIIF R Kumar, R Betney, J Li, EB Thompson, IJ McEwan Biochemistry 43 (11), 3008-3013, 2004 | 136 | 2004 |
| Structural Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies … DN Lavery, IJ McEwan Biochemistry 47 (11), 3360-3369, 2008 | 122 | 2008 |
