| Pharmacological comparison of mitragynine and 7-hydroxymitragynine: in vitro affinity and efficacy for μ-opioid receptor and opioid-like behavioral effects in rats S Obeng, JL Wilkerson, F León, ME Reeves, LF Restrepo, ... The Journal of pharmacology and experimental therapeutics 376 (3), 410-427, 2021 | 88 | 2021 |
| Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors F León, S Obeng, M Mottinelli, Y Chen, TI King, EC Berthold, SH Kamble, ... Journal of medicinal chemistry 64 (18), 13510-13523, 2021 | 68 | 2021 |
| Efficient preparation of an N-aryl β-amino acid via asymmetric hydrogenation and direct asymmetric reductive amination en route to Ezetimibe GF Busscher, L Lefort, JGO Cremers, M Mottinelli, RW Wiertz, B de Lange, ... Tetrahedron: Asymmetry 21 (13-14), 1709-1714, 2010 | 45 | 2010 |
| Characterization of sigma 1 receptor antagonist CM-304 and its analog, AZ-66: novel therapeutics against allodynia and induced pain TJ Cirino, SO Eans, JM Medina, LL Wilson, M Mottinelli, S Intagliata, ... Frontiers in pharmacology 10, 678, 2019 | 43 | 2019 |
| Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5 C Granchi, S Roy, M Mottinelli, E Nardini, F Campinoti, T Tuccinardi, ... Bioorganic & medicinal chemistry letters 21 (24), 7331-7336, 2011 | 37 | 2011 |
| Directed biosynthesis of mitragynine stereoisomers C Schotte, Y Jiang, D Grzech, TTT Dang, LC Laforest, F León, M Mottinelli, ... Journal of the American Chemical Society 145 (9), 4957-4963, 2023 | 32 | 2023 |
| The lack of contribution of 7-hydroxymitragynine to the antinociceptive effects of mitragynine in mice: a pharmacokinetic and pharmacodynamic study EC Berthold, SH Kamble, KS Raju, MA Kuntz, AS Senetra, M Mottinelli, ... Drug Metabolism and Disposition 50 (2), 158-167, 2022 | 25 | 2022 |
| Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: structure-activity relationships of 6-acetyl-3-(4-(4-(4-fluorophenyl) piperazin-1-yl) butyl … HE Nicholson, WF Alsharif, AB Comeau, C Mesangeau, S Intagliata, ... The Journal of pharmacology and experimental therapeutics 368 (2), 272-281, 2019 | 24 | 2019 |
| Characterization of CM-398, a novel selective sigma-2 receptor ligand, as a potential therapeutic for neuropathic pain LL Wilson, AR Alleyne, SO Eans, TJ Cirino, HM Stacy, M Mottinelli, ... Molecules 27 (11), 3617, 2022 | 18 | 2022 |
| Metabolism of speciociliatine, an overlooked kratom alkaloid for its potential pharmacological effects SH Kamble, EC Berthold, SRR Kanumuri, TI King, MA Kuntz, F León, ... The AAPS journal 24 (5), 86, 2022 | 17 | 2022 |
| Highly specific sigma receptor ligands exhibit anti-viral properties in SARS-CoV-2 infected cells DA Ostrov, AP Bluhm, D Li, JQ Khan, M Rohamare, K Rajamanickam, ... Pathogens 10 (11), 1514, 2021 | 12 | 2021 |
| Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems M Mottinelli, MP Leese, BVL Potter Beilstein Journal of Organic Chemistry 13 (1), 1871-1878, 2017 | 11 | 2017 |
| Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule … YT Ortiz, JA Bilbrey, JS Felix, EA Kienegger, M Mottinelli, ... Pharmacological Reports 75 (4), 937-950, 2023 | 9 | 2023 |
| Identification and characterization of MAM03055A: A novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity CZ Liu, M Mottinelli, HE Nicholson, BM McVeigh, NK Wong, CR McCurdy, ... European journal of pharmacology 906, 174263, 2021 | 9 | 2021 |
| Pharmacological comparison of mitragynine and 7-hydroxymitragynine S Obeng, JL Wilkerson, F León, ME Reeves, LF Restrepo, ... vitro, 2021 | 9 | 2021 |
| Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue Theranostics 10 (18), 7938-7955, 2020 | 8 | 2020 |
| Serotonin 5‐HT1A Receptor Activity of Kratom Alkaloids Mitragynine, Paynantheine, and Speciogynine S Obeng, F Leon, A Patel, L Restrepo, L Gamez‐Jimenez, ... The FASEB Journal 35, 2021 | 5 | 2021 |
| N‐Phenyl‐1,2,3,4‐tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β‐Hydroxysteroid Dehydrogenase 1 Inhibitors M Mottinelli, M Sinreih, TL Rižner, MP Leese, BVL Potter ChemMedChem 16 (1), 259-291, 2021 | 5 | 2021 |
| The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α2 receptor activity in vitro and in vivo S Obeng, ML Crowley, M Mottinelli, F León, JDZ Gonzalez, Y Chen, ... European journal of pharmacology 980, 176863, 2024 | 3 | 2024 |
| In Vitro and In Vivo Pharmacological Comparison of Mu‐Opioid Receptor Activity of the Kratom (Mitragyna speciosa) Alkaloid Mitragynine and its Metabolite 7 … MPG Calvache, S Obeng, F Leon, LR Gamez‐Jimenez, A Patel, NP Ho, ... Alzheimer's & Dementia 17, e058605, 2021 | 3 | 2021 |