| The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ... Nature 452 (7184), 230-233, 2008 | 3294 | 2008 |
| Pyruvate kinase M2 is a phosphotyrosine-binding protein HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley Nature 452 (7184), 181-186, 2008 | 1200 | 2008 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 819 | 2012 |
| Evidence for an alternative glycolytic pathway in rapidly proliferating cells MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ... Science 329 (5998), 1492-1499, 2010 | 753 | 2010 |
| The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR RM Chin, X Fu, MY Pai, L Vergnes, H Hwang, G Deng, S Diep, ... Nature 510 (7505), 397-401, 2014 | 676 | 2014 |
| Metabolic state of glioma stem cells and nontumorigenic cells E Vlashi, C Lagadec, L Vergnes, T Matsutani, K Masui, M Poulou, ... Proceedings of the National Academy of Sciences 108 (38), 16062-16067, 2011 | 587 | 2011 |
| Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor AS Krall, S Xu, TG Graeber, D Braas, HR Christofk Nature communications 7 (1), 11457, 2016 | 516 | 2016 |
| Viral hijacking of cellular metabolism SK Thaker, J Ch’ng, HR Christofk BMC biology 17, 1-15, 2019 | 470 | 2019 |
| New aspects of the Warburg effect in cancer cell biology SJ Bensinger, HR Christofk Seminars in cell & developmental biology 23 (4), 352-361, 2012 | 404 | 2012 |
| Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism JC Schell, DR Wisidagama, C Bensard, H Zhao, P Wei, J Tanner, A Flores, ... Nature cell biology 19 (9), 1027-1036, 2017 | 302 | 2017 |
| Glycolytic metabolism plays a functional role in regulating human pluripotent stem cell state W Gu, X Gaeta, A Sahakyan, AB Chan, CS Hong, R Kim, D Braas, K Plath, ... Cell stem cell 19 (4), 476-490, 2016 | 300 | 2016 |
| Identification of small molecule inhibitors of pyruvate kinase M2 MG Vander Heiden, HR Christofk, E Schuman, AO Subtelny, H Sharfi, ... Biochemical pharmacology 79 (8), 1118-1124, 2010 | 287 | 2010 |
| Lactate dehydrogenase activity drives hair follicle stem cell activation A Flores, J Schell, AS Krall, D Jelinek, M Miranda, M Grigorian, D Braas, ... Nature cell biology 19 (9), 1017-1026, 2017 | 284 | 2017 |
| Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication M Thai, NA Graham, D Braas, M Nehil, E Komisopoulou, SK Kurdistani, ... Cell metabolism 19 (4), 694-701, 2014 | 284 | 2014 |
| A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen JM Asara, HR Christofk, LM Freimark, LC Cantley Proteomics 8 (5), 994-999, 2008 | 280 | 2008 |
| Histone acetylation regulates intracellular pH MA McBrian, IS Behbahan, R Ferrari, T Su, TW Huang, K Li, CS Hong, ... Molecular cell 49 (2), 310-321, 2013 | 277 | 2013 |
| 2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ... Cell metabolism 22 (3), 508-515, 2015 | 254 | 2015 |
| Doxycycline alters metabolism and proliferation of human cell lines E Ahler, WJ Sullivan, A Cass, D Braas, AG York, SJ Bensinger, ... PloS one 8 (5), e64561, 2013 | 232 | 2013 |
| Extracellular matrix remodeling regulates glucose metabolism through TXNIP destabilization WJ Sullivan, PJ Mullen, EW Schmid, A Flores, M Momcilovic, MS Sharpley, ... Cell 175 (1), 117-132. e21, 2018 | 227 | 2018 |
| MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4 CS Hong, NA Graham, W Gu, CE Camacho, V Mah, EL Maresh, M Alavi, ... Cell reports 14 (7), 1590-1601, 2016 | 227 | 2016 |
