| The PI3K pathway in human disease DA Fruman, H Chiu, BD Hopkins, S Bagrodia, LC Cantley, RT Abraham Cell 170 (4), 605-635, 2017 | 2495 | 2017 |
| Phosphoinositide 3-kinases DA Fruman Handbook of Cell Signaling (Second Edition), 1049-1060, 2009 | 2167* | 2009 |
| Phosphoinositide kinases DA Fruman, RE Meyers, LC Cantley Annual review of biochemistry 67 (1), 481-507, 1998 | 2167 | 1998 |
| Phosphoinositide kinases DA Fruman, RE Meyers, LC Cantley Annual review of biochemistry 67 (1), 481-507, 1998 | 2162 | 1998 |
| PI3K and cancer: lessons, challenges and opportunities DA Fruman, C Rommel Nature reviews Drug discovery 13 (2), 140-156, 2014 | 1904 | 2014 |
| Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. DA Fruman, CB Klee, BE Bierer, SJ Burakoff Proceedings of the National Academy of Sciences 89 (9), 3686-3690, 1992 | 1038 | 1992 |
| Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α DA Fruman, SB Snapper, CM Yballe, L Davidson, JY Yu, FW Alt, ... Science 283 (5400), 393-397, 1999 | 822 | 1999 |
| PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot, RH Jones, H Eng, ... Molecular Cancer 22 (1), 1-37, 2023 | 699 | 2023 |
| Phosphatidylinositol‐3, 4, 5‐trisphosphate (PtdIns‐3, 4, 5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals AM Scharenberg, O El‐Hillal, DA Fruman, LO Beitz, Z Li, S Lin, I Gout, ... The EMBO Journal 17 (7), 1961-1972, 1998 | 554 | 1998 |
| Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase HW Chang, M Aoki, D Fruman, KR Auger, A Bellacosa, PN Tsichlis, ... Science 276 (5320), 1848-1850, 1997 | 537 | 1997 |
| Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor MR Janes, JJ Limon, L So, J Chen, RJ Lim, MA Chavez, C Vu, MB Lilly, ... Nature medicine 16 (2), 205-213, 2010 | 481 | 2010 |
| Phosphoinositide 3-Kinase: Diverse Roles in Immune Cell Activation JA Deane, DA Fruman Annu. Rev. Immunol. 22, 563-598, 2004 | 474 | 2004 |
| Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α DA Fruman, F Mauvais-Jarvis, DA Pollard, CM Yballe, D Brazil, ... Nature genetics 26 (3), 379-382, 2000 | 383 | 2000 |
| Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival K Ueki, DA Fruman, SM Brachmann, YH Tseng, LC Cantley, CR Kahn Molecular and cellular biology 22 (3), 965-977, 2002 | 371 | 2002 |
| Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes F Mauvais-Jarvis, K Ueki, DA Fruman, MF Hirshman, K Sakamoto, ... The Journal of clinical investigation 109 (1), 141-149, 2002 | 355 | 2002 |
| Immunophilins in protein folding and immunosuppression1 DA Fruman, SJ Burakoff, BE Bierer The FASEB journal 8 (6), 391-400, 1994 | 335 | 1994 |
| Xid-like phenotypes: AB cell signalosome takes shape DA Fruman, AB Satterthwaite, ON Witte Immunity 13 (1), 1-3, 2000 | 294 | 2000 |
| Akt and mTOR in B cell activation and differentiation JJ Limon, DA Fruman Frontiers in immunology 3, 228, 2012 | 282 | 2012 |
| Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology BE Bierer, G Holländer, D Fruman, SJ Burakoff Current opinion in immunology 5 (5), 763-773, 1993 | 280 | 1993 |
| Phosphoinositide 3-kinase in immunological systems DA Fruman, LC Cantley Seminars in immunology 14 (1), 7-18, 2002 | 278 | 2002 |
