| Translational control is required for the unfolded protein response and in vivo glucose homeostasis D Scheuner, B Song, E McEwen, C Liu, R Laybutt, P Gillespie, ... Molecular cell 7 (6), 1165-1176, 2001 | 1662 | 2001 |
| Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring SF Ng, RCY Lin, DR Laybutt, R Barres, JA Owens, MJ Morris Nature 467 (7318), 963-966, 2010 | 1600 | 2010 |
| Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK Busch, AV Biankin, ... Diabetologia 50, 752-763, 2007 | 1057 | 2007 |
| Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes JC Jonas, A Sharma, W Hasenkamp, H Ilkova, G Patane, R Laybutt, ... Journal of Biological Chemistry 274 (20), 14112-14121, 1999 | 744 | 1999 |
| Beta-cell adaptation and decompensation during the progression of diabetes. GC Weir, DR Laybutt, H Kaneto, S Bonner-Weir, A Sharma Diabetes 50 (suppl_1), S154, 2001 | 649 | 2001 |
| Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes G Xu, H Kaneto, DR Laybutt, VF Duvivier-Kali, N Trivedi, K Suzuma, ... Diabetes 56 (6), 1551-1558, 2007 | 464 | 2007 |
| Alterations in microRNA expression contribute to fatty acid–induced pancreatic β-cell dysfunction P Lovis, E Roggli, DR Laybutt, S Gattesco, JY Yang, C Widmann, ... Diabetes 57 (10), 2728-2736, 2008 | 414 | 2008 |
| The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions M Bensellam, DR Laybutt, JC Jonas Molecular and cellular endocrinology 364 (1-2), 1-27, 2012 | 377 | 2012 |
| A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat ND Oakes, CJ Kennedy, AB Jenkins, DR Laybutt, DJ Chisholm, ... Diabetes 43 (10), 1203-1210, 1994 | 323 | 1994 |
| Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets K Cheng, K Ho, R Stokes, C Scott, SM Lau, WJ Hawthorne, PJ O’connell, ... The Journal of clinical investigation 120 (6), 2171-2183, 2010 | 309 | 2010 |
| Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to β-cell survival during chronic hyperglycemia DR Laybutt, H Kaneto, W Hasenkamp, S Grey, JC Jonas, DC Sgroi, ... Diabetes 51 (2), 413-423, 2002 | 296 | 2002 |
| Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions M Bensellam, JC Jonas, DR Laybutt Journal of Endocrinology 236 (2), R109-R143, 2018 | 272 | 2018 |
| Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes V Nesca, C Guay, C Jacovetti, V Menoud, ML Peyot, DR Laybutt, ... Diabetologia 56, 2203-2212, 2013 | 260 | 2013 |
| Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia DR Laybutt, A Sharma, DC Sgroi, J Gaudet, S Bonner-Weir, GC Weir Journal of Biological Chemistry 277 (13), 10912-10921, 2002 | 239 | 2002 |
| Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis AK Busch, E Gurisik, DV Cordery, M Sudlow, GS Denyer, DR Laybutt, ... Diabetes 54 (10), 2917-2924, 2005 | 210 | 2005 |
| Circular RNAs as novel regulators of β-cell functions in normal and disease conditions L Stoll, J Sobel, A Rodriguez-Trejo, C Guay, K Lee, MT Venø, J Kjems, ... Molecular metabolism 9, 69-83, 2018 | 202 | 2018 |
| Critical reduction in β-cell mass results in two distinct outcomes over time: adaptation with impaired glucose tolerance or decompensated diabetes DR Laybutt, M Glandt, G Xu, YB Ahn, N Trivedi, S Bonner-Weir, GC Weir Journal of Biological Chemistry 278 (5), 2997-3005, 2003 | 189 | 2003 |
| MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity C Jacovetti, A Abderrahmani, G Parnaud, JC Jonas, ML Peyot, M Cornu, ... The Journal of clinical investigation 122 (10), 3541-3551, 2012 | 187 | 2012 |
| A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking E Boslem, G MacIntosh, AM Preston, C Bartley, AK Busch, M Fuller, ... Biochemical Journal 435 (1), 267-276, 2011 | 187 | 2011 |
| Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload AM Preston, E Gurisik, C Bartley, DR Laybutt, TJ Biden Diabetologia 52, 2369-2373, 2009 | 182 | 2009 |
