متابعة
Alejandro E. Leroux
Alejandro E. Leroux
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)
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عنوان
عدد مرات الاقتباسات
عدد مرات الاقتباسات
السنة
AGC kinases, mechanisms of regulation‎ and innovative drug development
AE Leroux, JO Schulze, RM Biondi
Seminars in cancer biology 48, 1-17, 2018
1452018
Low-molecular-mass antioxidants in parasites
RL Krauth-Siegel, AE Leroux
Antioxidants & redox signaling 17 (4), 583-607, 2012
1202012
Thiol redox biology of trypanosomatids and potential targets for chemotherapy
AE Leroux, RL Krauth-Siegel
Molecular and Biochemical Parasitology 206 (1-2), 67-74, 2016
1122016
Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei
S Zimmermann, M Oufir, A Leroux, RL Krauth-Siegel, K Becker, M Kaiser, ...
Bioorganic & medicinal chemistry 21 (22), 7202-7209, 2013
482013
Renaissance of allostery to disrupt protein kinase interactions
AE Leroux, RM Biondi
Trends in Biochemical Sciences 45 (1), 27-41, 2020
462020
ACE2, the receptor that enables infection by SARS‐CoV‐2: Biochemistry, structure, allostery and evaluation of the potential development of ACE2 modulators
LZF Gross, M Sacerdoti, A Piiper, S Zeuzem, AE Leroux, RM Biondi
ChemMedChem 15 (18), 1682-1690, 2020
442020
Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi
AE Leroux, DA Maugeri, JJ Cazzulo, C Nowicki
Molecular and biochemical parasitology 177 (1), 61-64, 2011
422011
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling
AE Leroux, JR Haanstra, BM Bakker, RL Krauth-Siegel
Journal of Biological Chemistry 288 (33), 23751-23764, 2013
352013
Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei
AE Leroux, DA Maugeri, FR Opperdoes, JJ Cazzulo, C Nowicki
FEMS microbiology letters 314 (1), 25-33, 2011
352011
Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp.
A Leroux, X Fleming-Canepa, A Aranda, D Maugeri, JJ Cazzulo, ...
Molecular and biochemical parasitology 149 (1), 74-85, 2006
282006
An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone
RB Currier, K Ulrich, AE Leroux, N Dirdjaja, M Deambrosi, M Bonilla, ...
PLoS Pathogens 15 (9), e1008065, 2019
192019
Molecular and functional characterization of two malic enzymes from Leishmania parasites
L Giordana, MH Sosa, AE Leroux, EFR Mendoza, P Petray, C Nowicki
Molecular and Biochemical Parasitology 219, 67-76, 2018
102018
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
M Sacerdoti, LZF Gross, AM Riley, K Zehnder, A Ghode, S Klinke, ...
Science signaling 16 (789), eadd3184, 2023
92023
The silicon trypanosome: a test case of iterative model extension in systems biology
F Achcar, A Fadda, JR Haanstra, EJ Kerkhoven, DH Kim, AE Leroux, ...
Advances in microbial physiology 64, 115-143, 2014
92014
The choreography of protein kinase PDK1 and its diverse substrate dance partners
AE Leroux, RM Biondi
Biochemical Journal 480 (19), 1503-1532, 2023
82023
The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B
L Alcober‐Boquet, T Zang, L Pietsch, E Suess, M Hartmann, E Proschak, ...
Protein Science, e4840, 2023
52023
Allosteric regulation of protein kinases downstream of PI3-kinase signalling
AE Leroux, LZF Gross, M Sacerdoti, RM Biondi
Protein Allostery in Drug Discovery, 279-311, 2019
52019
The role of S-adenosylhomocysteine hydrolase-like 1 in cancer
N Budnik, A Leroux, M Cooke, MG Kazanietz, C Vigliano, K Kobayashi, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 119819, 2024
12024
Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds
LZF Gross, AF Winkel, F Galceran, JO Schulze, W Fröhner, S Cämmerer, ...
Journal of biological chemistry 300 (8), 2024
2024
Chemical biology and structural studies on the mechanism of regulation of phosphoinositide-dependent protein kinase 1 (PDK1)
LZF Gross, M Sacerdoti, AE Leroux, A Ghode, GS Anand, JO Schulze, ...
Acta Cryst 77, C1114, 2021
2021
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مقالات 1–20