متابعة
Tom Wennekes
Tom Wennekes
Utrecht University, Department of Chemical Biology and Drug Discovery
بريد إلكتروني تم التحقق منه على uu.nl - الصفحة الرئيسية
عنوان
عدد مرات الاقتباسات
عدد مرات الاقتباسات
السنة
Multivalent glycoconjugates as anti-pathogenic agents‏
A Bernardi, J Jiménez-Barbero, A Casnati, C De Castro, T Darbre, ...‏
Chemical Society Reviews 42 (11), 4709-4727, 2013‏
5922013
Glycosphingolipids—nature, function, and pharmacological modulation‏
T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ...‏
Angewandte Chemie International Edition 48 (47), 8848-8869, 2009‏
3732009
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity‏
JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ...‏
Diabetes 56 (5), 1341-1349, 2007‏
3442007
Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2‏
RG Boot, M Verhoek, W Donker-Koopman, A Strijland, J Van Marle, ...‏
Journal of Biological Chemistry 282 (2), 1305-1312, 2007‏
2512007
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity‏
JH Kim, R Resende, T Wennekes, HM Chen, N Bance, S Buchini, ...‏
Science 340 (6128), 71-75, 2013‏
2262013
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man‏
T Wennekes, RJ van den Berg, W Donker, GA van der Marel, A Strijland, ...‏
The Journal of organic chemistry 72 (4), 1088-1097, 2007‏
1722007
Hydrolytic and thermal stability of organic monolayers on various inorganic substrates‏
NS Bhairamadgi, SP Pujari, FG Trovela, A Debrassi, AA Khamis, ...‏
Langmuir 30 (20), 5829-5839, 2014‏
1202014
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation‏
T Wennekes, AJ Meijer, AK Groen, RG Boot, JE Groener, M van Eijk, ...‏
Journal of medicinal chemistry 53 (2), 689-698, 2010‏
1162010
N-glycolylneuraminic acid as a receptor for influenza A viruses‏
F Broszeit, N Tzarum, X Zhu, N Nemanichvili, D Eggink, T Leenders, Z Li, ...‏
Cell reports 27 (11), 3284-3294. e6, 2019‏
982019
A protein‐based pentavalent inhibitor of the cholera toxin B‐subunit‏
TR Branson, TE McAllister, J Garcia‐Hartjes, MA Fascione, JF Ross, ...‏
Angewandte Chemie 126 (32), 8463-8467, 2014‏
982014
Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase‏
AJ Thompson, RJ Williams, Z Hakki, DS Alonzi, T Wennekes, TM Gloster, ...‏
Proceedings of the National Academy of Sciences 109 (3), 781-786, 2012‏
872012
A fluorescence polarization activity-based protein profiling assay in the discovery of potent, selective inhibitors for human nonlysosomal glucosylceramidase‏
D Lahav, B Liu, RJ van den Berg, AMCH van den Nieuwendijk, ...‏
Journal of the American Chemical Society 139 (40), 14192-14197, 2017‏
742017
The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation‏
N Dekker, T Voorn-Brouwer, M Verhoek, T Wennekes, RS Narayan, ...‏
Blood Cells, Molecules, and Diseases 46 (1), 19-26, 2011‏
742011
Glycosphingolipids and insulin resistance‏
JM Aerts, RG Boot, M van Eijk, J Groener, N Bijl, E Lombardo, FM Bietrix, ...‏
Sphingolipids and metabolic disease, 99-119, 2011‏
712011
Getting a grip on glycans: a current overview of the metabolic oligosaccharide engineering toolbox‏
TJ Sminia, H Zuilhof, T Wennekes‏
Carbohydrate research 435, 121-141, 2016‏
662016
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors‏
AT Ghisaidoobe, RJ van den Berg, SS Butt, A Strijland, ...‏
Journal of medicinal chemistry 57 (21), 9096-9104, 2014‏
652014
Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix [5] arene‏
J Garcia-Hartjes, S Bernardi, CAGM Weijers, T Wennekes, M Gilbert, ...‏
Organic & biomolecular chemistry 11 (26), 4340-4349, 2013‏
642013
Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism‏
T Wennekes, RJ van den Berg, KM Bonger, WE Donker-Koopman, ...‏
Tetrahedron: Asymmetry 20 (6-8), 836-846, 2009‏
572009
Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin‏
T Wennekes, B Lang, M Leeman, GA Marel, E Smits, M Weber, ...‏
Organic Process Research & Development 12 (3), 414-423, 2008‏
562008
Clickable polylactic acids by fast organocatalytic ring-opening polymerization in continuous flow‏
SA Van Den Berg, H Zuilhof, T Wennekes‏
Macromolecules 49 (6), 2054-2062, 2016‏
502016
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مقالات 1–20